Proceedings: Surface antigens of leukaemic cells

Interferon resistance in leukaemic cells and lysosome stability [proceedings].

The anti-viral effect of interferon can be at least partly ascribed to an inhibitionoftranslation. The results of Kerr et al. ( I 974) and Content et al. (1975) suggested that a doublestranded RNA is a possible mediator of the effect of interferon on protein synthesis. On the other hand, interferon is known to potentiate the cytotoxic effect of doublestranded RNA (Stewart et al., 1972) and to i...

Surface Antigens of Immunocompetent Cells

The effect of preincubation with anti-theta or anti-mouse immunoglobulin (Ig) and complement (C') on immune responsiveness of spleen cells from BALB/c mice immunized with sheep erythrocytes (SE) was investigated. Both treatments greatly depressed the remaining ability to produce a secondary response to SE in vitro. Normal BALB/c spleen cells were far less effective in reconstituting the respons...

Cytochemistry of leukaemic lymphoid cells.

Surface Antigens of Human Nk Cells

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Normal and leukaemic stem cells.

The blood-related cancer leukaemias were the first diseases where human cancer stem cells, or leukaemic stem cells (LSC), were isolated. The haematopoietic system is one of the best tissues for investigating cancer stem cells, because the developmental hierarchy of normal blood formation is well defined. Leukaemias can now be viewed as aberrant haematopoietic processes initiated by rare LSC tha...